• The different serotypes A G have

  2021-07-23

  

  The different serotypes (A-G) have unique receptors to which they bind to produce the toxic effect on the nerve cells. (Lance, 2004, Rosetto et al., 2014). Intracellularly, the endopeptidase activity of different serotypes of BoNT target selectively a unique group of proteins, the SNARE xanthine oxi

• Adapalene mg To elucidate whether the impact of hypoxia on E

  2021-07-23

  

  To elucidate whether the impact of hypoxia on EGFR expression is cell context specific or culturing density dependent, we chose the following cancer Adapalene mg driven by EGFR and evaluated the EGFR expression after hypoxia treatment at different culturing density: a highly aggressive and poorly d

• One of the hallmarks of the terminal

  2021-07-23

  

  One of the hallmarks of the terminal stages of apoptosis is the fragmentation of chromosomal DNA that proceeds in a two-step manner: the DNA is initially cleaved into 50–300kb fragments and eventually into oligonucleosomal pieces [12], [13]. The two major apoptotic nucleases are DNA fragmentation fa

• In attempts to further purify

  2021-07-23

  

  In attempts to further purify [His]6-Artemis, numerous matrices were assessed including anion and cation exchange, and SCH527123 interaction chromatography. The results from these matrices were universally poor (data not shown). Fractionation via adsorption chromatography on a hydroxyapatite (HAP)

• br Materials and methods br Discussion To date only

  2021-07-23

  

  Materials and methods Discussion To date, only a fraction of studies pertaining to analysis of avian semen have focused on the study of DNA, with the vast majority being associated with the effects of cryopreservation on sperm DNA integrity (Kotłowska et al., 2007, Madeddu et al., 2009, Partyk

• br The related catalytic regions of

  2021-07-23

  

  The related catalytic regions of the human DNA ligases contain three domains, a DNA binding domain (DBD), a nucleotidyl transferase domain (NTase) and an oligonucleotide/oligosaccharide-fold binding domain (OBD) (Ellenberger and Tomkinson, 2008). Similar to DNA ligase I, the DNA ligase III polypep

• In this review focusing on biocatalyst formate

  2021-07-23

  

  In this review, focusing on biocatalyst “formate dehydrogenase FDH” catalyzing both of the formic fk866 oxidation to CO2 and the CO2 reduction to formic acid, representative examples of properties, types, structure of active-site of FDH and, reaction mechanism of formic acid oxidation and CO2 reduc

• AQP protein expression was determined

  2021-07-23

  

  AQP4 protein expression was determined by Western blot analysis. Briefly, protein samples (50μg) from brains or astrocytes were separated by 12% SDS–polyacrylamide gel electrophoresis and transferred to nitrocellulose membranes. The membranes were reacted with a rabbit polyclonal antibody against AQ

• CIC mediated chemoresistance is driven by several factors

  2021-07-23

  

  CIC-mediated chemoresistance is driven by several factors. In our quest to learn about these, we examined the crucial mediators identified earlier in the regulation of CSC survival and chemoresistance, such as BCL2, cleaved Caspase-3, COX-2, and macrophages. Interestingly, we observed a significantl

• This review focuses on the atomic

  2021-07-22

  

  This review focuses on the atomic basis of CRM1-mediated nuclear export. There are now 27 crystal structures of CRM1 in the Protein Data Bank (PDB) (www.rcsb.org) [64]. Collectively, this large body of work explains various aspects of CRM1 function. Here we summarize the structure–function studies t

• Taking into account that a PFOS

  2021-07-22

  

  Taking into account that: (a) PFOS inhibits CRF gene expression as well as CRF and corticosterone secretion (Pereiro et al., 2014); (b) CRF1r mediates the stimulation of the pituitary ACTH secretion by this neuropeptide (Rivier et al., 2003); (c) corticosterone regulates its own synthesis by a negat

• The aim of this study was

  2021-07-22

  

  The aim of this study was to use molecular methods to characterise C. difficile isolates circulating in the Czech Republic from 2013 to 2015. Material and methods Discussion During a three-year period (2013–2015) a total of 32 hospitals voluntarily participated in this project, but only 11 ho

• Materials and methods br Results br Discussion Microbial pro

  2021-07-22

  

  Materials and methods Results Discussion Microbial production of trans-4Hyp, an added-value amino signal transducer and activator of transcription 6 fragment synthesis for pharmaceuticals, offers significant advantages over conventional chemical extraction in economic and environmental aspec

• Moreover as shown in Fig f while the

  2021-07-22

  

  Moreover, as shown in Fig. 5f, while the knockdown of SMURF2 in wild-type rp gift card has no significant effect on HSP27, in CK2α/α′(−/−) cells it leads to an increase of HSP27 level. These results suggest that SMURF2 affects HSP27 protein stability only when overexpressed, at least in our cell mo

• Another potential source of variable affinities is inherent

  2021-07-22

  

  Another potential source of variable affinities is inherent in the method of RBA determination. While several reports simply use relative IC50 values as RBAs [11], [12], [13], [14], [15], these are only an approximate measure of relative affinity since IC50 varies due to experimental and biological

15362 records 631/1025 page Previous Next First page 上5页 631632633634635 下5页 Last page