• Biotin-binding fluorescent protein The loss of synaptic prot

  2025-02-05

  

  The loss of synaptic proteins such as synaptophysin from the Biotin-binding fluorescent protein is indicative of synapse degeneration and provided a good correlate of the degree of dementia in AD [12], [13], [14]. Consequently, the loss of synaptic proteins from cultured primary neurons incubated wi

• sanguinarine br The lipoxygenase pathway in

  2025-02-05

  

  The 12/15-lipoxygenase pathway in diseases of the nervous system Conclusions and future perspectives Arachidonic sanguinarine and other polyunsaturated fatty acids, and their lipid metabolites, play very important roles in human health and disease. This review has outlined the functions of 12

• In our previous study we showed that normal and cancerous

  2025-02-05

  

  In our previous study we showed that normal and cancerous dihydromyricetin alcohol of kidney exhibit the activity of alcohol dehydrogenase and aldehyde dehydrogenase. Furthermore, the activity of class I ADH isoenzymes and total ADH were significantly higher in cancer tissue than in unchanged renal

• br Funding This work was supported by Arena Pharmaceuticals

  2025-02-05

  

  Funding This work was supported by Arena Pharmaceuticals, Inc, San Diego, CA, USA. Introduction 5-hydroxytryptamine 1B (5-HT1B) receptors are widely distributed in the central nervous system (CNS); they have various modulatory functions in drug reinforcement, appetitive behaviors, stress, moo

• A highly attenuated B pertussis strain named BPZE has

  2025-02-05

  

  A highly attenuated B. pertussis strain, named BPZE1, has recently been described [10]. It produces enzymatically inactive pertussis toxin (PT), no dermonecrotic toxin and only trace amounts of tracheal cytotoxin. Markedly reduced lung pathology was observed in mice intranasally (i.n.) infected with

• SZL P1-41 Numerous studies have shown that

  2025-02-05

  

  Numerous studies have shown that ω-3 PUFA incorporation into the lipid raft can affect the distribution and function of protein in the lipid raft by altering raft composition [25], [26], [27]. For example, DHA treatment excluded phospholipase D (PLD) from lipid raft toward non-lipid raft, resulting

• br Conflict of interest br Acknowledgements The authors woul

  2025-02-05

  

  Conflict of interest Acknowledgements The authors would like to thank Mrs. Amparo Pacheco from CMPL, PUC, for her technical and secretarial assistance. This work was supported by the Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT 1150344, 1050377, 11150083), and the Direccioń

• REM sleep is proposed to create an

  2025-02-05

  

  REM sleep is proposed to create an environment to facilitate plasticity processes that create a generalized downregulation of synaptic strength (Grosmark et al., 2012; Tononi and Cirelli, 2014), while synapses are upregulated specifically by the reactivation of neuronal firing sequences experienced

• In the present study the

  2025-02-05

  

  In the present study, the alternative splicing of several nAChR subunits was identified in the oriental migratory locust (Locusta migratoria manilensis Meyen), a serious worldwide pest to agricultural production and also a model insect species [5]. Several α subunits were tried to co-express with ra

• br Funding This work was supported

  2025-02-05

  

  Funding This work was supported by Arena Pharmaceuticals, Inc, San Diego, CA, USA. Introduction 5-hydroxytryptamine 1B (5-HT1B) receptors are widely distributed in the central nervous system (CNS); they have various modulatory functions in drug reinforcement, appetitive behaviors, stress, moo

• br Results and discussion This

  2025-02-03

  

  Results and discussion This paper reports the synthesis of methoxy and 4-thio derivatives of quercetin and luteolin, which includes two new derivatives (4 and 12) and explores how subtle variations in the chemical structure of flavonoids affect their biological activity, particularly in relation

• br Concluding remarks The past decade has

  2025-02-01

  

  Concluding remarks The past decade has seen rapid advances in our understanding of the metabolic reprogramming that occurs during tumorigenesis. Strategies to target specific nodes of cancer cell amino additional hints metabolism have progressed from preclinical studies to clinical trials, and a

• br Experimental section br Introduction Microglia

  2025-02-01

  

  Experimental section Introduction Microglia were discovered as a novel cell population in Colorectal cancer treatment in 1933 by a Spanish physician and histologist Pío del Río-Hortega [1]. In the eye, scientists used Hortega's staining technique to label the microglia in the retinal outer pl

• The functional observations from the present study are based

  2025-02-01

  

  The functional observations from the present study are based on neoplastic Mifepristone (HSY), and comparative expressions between normal salivary and pleomorphic adenoma tissues. However, there is a paucity of information on AhR expression and function in normal salivary gland, not neoplastic, cel

• Circulating adrenal derived stress hormones epinephrine and

  2025-02-01

  

  Circulating adrenal-derived stress hormones, epinephrine and corticosterone mediate their tissue effects through adrenergic (AR; α and β) and glucocorticoid (GR) receptors. AR are widely distributed throughout the body and although epinephrine is a prototypical agonist for all types of AR, the selec

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